human monocytes. Our studies have characterized the functional IL-13 receptor complex
and the downstream signaling events in response to IL-13 stimulation in alternatively
activated monocytes/macrophages. In this report, we present evidence that IL-13 induces
the activation of a Src family tyrosine kinase, which is required for IL-13 induction of M2 gene
expression, including 15-lipoxygenase (15-LO). Our data show that Src kinase activity …