Hck is a key regulator of gene expression in alternatively activated human monocytes
A Bhattacharjee, S Pal, GM Feldman… - Journal of Biological …, 2011 - ASBMB
IL-13 is a Th2 cytokine that promotes alternative activation (M2 polarization) in primary
human monocytes. Our studies have characterized the functional IL-13 receptor complex
and the downstream signaling events in response to IL-13 stimulation in alternatively
activated monocytes/macrophages. In this report, we present evidence that IL-13 induces
the activation of a Src family tyrosine kinase, which is required for IL-13 induction of M2 gene
expression, including 15-lipoxygenase (15-LO). Our data show that Src kinase activity …
human monocytes. Our studies have characterized the functional IL-13 receptor complex
and the downstream signaling events in response to IL-13 stimulation in alternatively
activated monocytes/macrophages. In this report, we present evidence that IL-13 induces
the activation of a Src family tyrosine kinase, which is required for IL-13 induction of M2 gene
expression, including 15-lipoxygenase (15-LO). Our data show that Src kinase activity …
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