The distribution of heavy metals: manganese, chromium, cadmium, copper, arsenate, iron and lead together with lipid profiles were investigated in the stomach of cow grazed in Akungba-Akoko region of Ondo State, Nigeria. This sample was analyzed using Atomic Absorption Spectrophotometric method (AAS) with wet digestion method. The results showed that the heavy metals concentrations in the stomach of the cows are: Mn (1.04±0.010 mg/g), Cr (1.85±0.18 mg/g), Cd (0.055±0.007 mg/g), Cu (2.525±0.261 mg/g), Fe (5.59±0.806 mg/g), Pb (0.065±0.08 mg/g) and As (0.165±0.021 mg/g). Also the lipid profile of the stomach of the cow was analyzed using thin layer chromatography. The result obtained was 10.71% phosphatidylcholine, 21.43% phosphatidylethanolamine, 25.0% phosphatidic acid and 42.64% triacylglycerol. The data obtained showed that human consumption of cow stomach may pose a risk of heavy metal toxicosis and hyperlipidemia.