Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection
M Jaramillo, I Plante, N Ouellet, K Vandal… - The Journal of …, 2004 - journals.aai.org
During malaria infection, high levels of proinflammatory molecules (eg, cytokines,
chemokines) correlate with disease severity. Even if their role as activators of the host
immune response has been studied, the direct contribution of hemozoin (HZ), a parasite
metabolite, to such a strong induction is not fully understood. Previous in vitro studies
demonstrated that both Plasmodium falciparum HZ and synthetic HZ (sHZ), β-hematin,
induce macrophage/monocyte chemokine and proinflammatory cytokine secretion. In the …
chemokines) correlate with disease severity. Even if their role as activators of the host
immune response has been studied, the direct contribution of hemozoin (HZ), a parasite
metabolite, to such a strong induction is not fully understood. Previous in vitro studies
demonstrated that both Plasmodium falciparum HZ and synthetic HZ (sHZ), β-hematin,
induce macrophage/monocyte chemokine and proinflammatory cytokine secretion. In the …
[PDF][PDF] Hemozoin-Inducible Proinflammatory Events
PAT Vandal, M Olivier - J Immunol, 2004 - Citeseer
During malaria infection, high levels of proinflammatory molecules (eg, cytokines,
chemokines) correlate with disease severity. Even if their role as activators of the host
immune response has been studied, the direct contribution of hemozoin (HZ), a parasite
metabolite, to such a strong induction is not fully understood. Previous in vitro studies
demonstrated that both Plasmodium falciparum HZ and synthetic HZ (sHZ),-hematin, induce
macrophage/monocyte chemokine and proinflammatory cytokine secretion. In the present …
chemokines) correlate with disease severity. Even if their role as activators of the host
immune response has been studied, the direct contribution of hemozoin (HZ), a parasite
metabolite, to such a strong induction is not fully understood. Previous in vitro studies
demonstrated that both Plasmodium falciparum HZ and synthetic HZ (sHZ),-hematin, induce
macrophage/monocyte chemokine and proinflammatory cytokine secretion. In the present …
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