Heparin binding epidermal growth factor-like growth factor heals chronic tympanic membrane perforations with advantage over fibroblast growth factor 2 and …
PL Santa Maria, K Weierich, S Kim… - Otology & …, 2015 - journals.lww.com
PL Santa Maria, K Weierich, S Kim, YP Yang
Otology & Neurotology, 2015•journals.lww.comBackground A nonsurgical treatment for chronic TM perforation would benefit those unable
to access surgery or those unable to have surgery, as well as reducing the cost of
tympanoplasty. Growth factor (GF) treatments have been reported in the literature with
variable success with the lack of a suitable animal providing a major obstacle. Methods The
GFs were tested in a validated mouse model of chronic TM perforation. A bioabsorbable
hydrogel polymer was used to deliver the GF at a steady concentration as it dissolved over 4 …
to access surgery or those unable to have surgery, as well as reducing the cost of
tympanoplasty. Growth factor (GF) treatments have been reported in the literature with
variable success with the lack of a suitable animal providing a major obstacle. Methods The
GFs were tested in a validated mouse model of chronic TM perforation. A bioabsorbable
hydrogel polymer was used to deliver the GF at a steady concentration as it dissolved over 4 …
Background
A nonsurgical treatment for chronic TM perforation would benefit those unable to access surgery or those unable to have surgery, as well as reducing the cost of tympanoplasty. Growth factor (GF) treatments have been reported in the literature with variable success with the lack of a suitable animal providing a major obstacle.
Methods
The GFs were tested in a validated mouse model of chronic TM perforation. A bioabsorbable hydrogel polymer was used to deliver the GF at a steady concentration as it dissolved over 4 weeks. A control (polymer only, n= 18) was compared to polymer loaded with HB-EGF (5 μg/ml, n= 18), FGF2 (100 μg/ml, n= 19), and EGF (250 μg/ml, n= 19). Perforations were inspected at 4 weeks.
Results
The healing rates, as defined as 100% perforation closure, were control (5/18, 27.8%), HB-EGF (15/18, 83.3%), FGF2 (6/19, 31.6%), and EGF (3/19, 15.8%). There were no differences between FGF2 (p= 0.80) and EGF (p= 0.31) with control healing rates. HB-EGF (p= 0.000001) showed a significant difference for healing. The HB-EGF healed TMs showed layers similar to a normal TM, whereas the other groups showed a lack of epithelial migration.
Conclusion
This study confirms the advantage of HB-EGF over two other commonly used growth factors and is a promising nonsurgical treatment of chronic TM perforations.
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