[HTML][HTML] Herpes simplex virus encephalitis in hamadan, iran
Iranian Journal of Microbiology, 2013•ncbi.nlm.nih.gov
Materials and Methods Diagnosis of encephalitis for these patients was firstly based on a
clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA
by PCR in CSF or brain neuro-imaging results. Results Molecular testing on CSF showed
that 15 patients (15%) had HSV infection, 5 patients (5%) had Varicella Zoster Virus (VZV)
and one case was positive for Human Immunodeficiency Virus (HIV)-RNA in CSF. The
cause of encephalitis in 79 out of 100 patients (79%) was unknown. The comparison of CSF …
clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA
by PCR in CSF or brain neuro-imaging results. Results Molecular testing on CSF showed
that 15 patients (15%) had HSV infection, 5 patients (5%) had Varicella Zoster Virus (VZV)
and one case was positive for Human Immunodeficiency Virus (HIV)-RNA in CSF. The
cause of encephalitis in 79 out of 100 patients (79%) was unknown. The comparison of CSF …
Materials and Methods
Diagnosis of encephalitis for these patients was firstly based on a clinical profile for Herpes Simplex Encephalitis (HSE), plus either a detected HSV1&2-DNA by PCR in CSF or brain neuro-imaging results.
Results
Molecular testing on CSF showed that 15 patients (15%) had HSV infection, 5 patients (5%) had Varicella Zoster Virus (VZV) and one case was positive for Human Immunodeficiency Virus (HIV)-RNA in CSF. The cause of encephalitis in 79 out of 100 patients (79%) was unknown. The comparison of CSF analysis in HSV positives and negatives showed a significant increase of glucose and protein levels in HSV positives than negatives. The mortality rate was 46.6%(7/15) in patients with HSV encephalitis compared to 11.4%(10/85) in non-HSV encephalitis (P= 0.003).
Conclusions
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