Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation
Chromosome conformation capture-based methods such as Hi-C have become mainstream
techniques for the study of the 3D organization of genomes. These methods convert
chromatin interactions reflecting topological chromatin structures into digital information
(counts of pair-wise interactions). Here, we describe an updated protocol for Hi-C (Hi-C 2.0)
that integrates recent improvements into a single protocol for efficient and high-resolution
capture of chromatin interactions. This protocol combines chromatin digestion and frequently …
techniques for the study of the 3D organization of genomes. These methods convert
chromatin interactions reflecting topological chromatin structures into digital information
(counts of pair-wise interactions). Here, we describe an updated protocol for Hi-C (Hi-C 2.0)
that integrates recent improvements into a single protocol for efficient and high-resolution
capture of chromatin interactions. This protocol combines chromatin digestion and frequently …
HI-C 2.0: An Optimized Hi-C Procedure for High-Resolution Genome-Wide Mapping of Chromosome Conformation [preprint]
H Belaghzal, J Dekker, JH Gibcus - 2016 - repository.escholarship.umassmed …
Chromosome conformation capture-based methods such as Hi-C have become mainstream
techniques for the study of the 3D organization of genomes. These methods convert
chromatin interactions reflecting topological chromatin structures into digital information
(counts of pair-wise interactions). Here, we describe an updated protocol for Hi-C (Hi-C 2.0)
that integrates recent improvements into a single protocol for efficient and high-resolution
capture of chromatin interactions. This protocol combines chromatin digestion and frequently …
techniques for the study of the 3D organization of genomes. These methods convert
chromatin interactions reflecting topological chromatin structures into digital information
(counts of pair-wise interactions). Here, we describe an updated protocol for Hi-C (Hi-C 2.0)
that integrates recent improvements into a single protocol for efficient and high-resolution
capture of chromatin interactions. This protocol combines chromatin digestion and frequently …
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