Current transcranial magnetic stimulation devices apply intense (near 1 tesla) repetitive magnetic pulses over a specific area of the skull at relatively lower frequencies (1‐50 Hz). Nevertheless, different studies have shown that very small magnetic fields, at higher frequencies (50‐1000 Hz.), produce therapeutic effects in major depressive disorder. We report the application of high‐frequency and low‐intensity patterned magnetic pulses over the left prefrontal dorsolateral cortex in three subjects diagnosed with clinical major depressive disorder. All three patients showed sharp changes in their self‐reports as well as in the standardized clinical assessment. Hypothesized mechanisms of action of this new variant of magnetic stimulation are discussed.