High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

A Sturchio, AK Dwivedi, CB Young, T Malm… - …, 2021 - thelancet.com
… We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are
associated with normal cognition and hippocampal volume despite increasing brain amyloidosis. …

High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer's Disease-Causing Mutations

A Sturchio, AK Dwivedi, T Malm… - Journal of …, 2022 - journals.sagepub.com
… soluble 42-amino acid amyloid-β (Aβ 42 ) levels are associated with … -positive individuals,
we found that higher CSF42 levels were associated with greater odds of normal cognition

CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease

A Siderowf, SX Xie, H Hurtig, D Weintraub, J Duda… - Neurology, 2010 - AAN Enterprises
CSF was collected at baseline and cognition was assessed at … CSF was tested for amyloid
β 1-42 (Aβ 1-42 ), p-tau 181p , and … CSF Aβ 1-42 was associated with more rapid cognitive

Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography

S Palmqvist, N Mattsson, O Hansson… - Brain, 2016 - academic.oup.com
… found that the CSF+/PET− group had similar baseline cognitive function, hippocampal …
CSF amyloid-β 42 levels associated with increased atrophy rates in Alzheimer’s disease-related

[HTML][HTML] Cognitive impairment and decline in cognitively normal older adults with high amyloid-β: a meta-analysis

JE Baker, YY Lim, RH Pietrzak, J Hassenstab… - Alzheimer's & dementia …, 2017 - Elsevier
… in CN older adults, reliable Aβ+ related cognitive impairment … be a 42% chance of picking
an Aβ+ individual at random that … than those using CSF to measure Aβ might be because CSF

Amyloid-β 42 is associated with cognitive impairment in healthy elderly and subjective cognitive impairment

S Rolstad, AI Berg, M Bjerke, K Blennow… - Journal of …, 2011 - content.iospress.com
cognition is related to CSF biomarkers regardless of impairment level. Aß42 is associated
with cognitive … Our results suggest that cognition is related to CSF biomarkers regardless of …

Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia

T Skillbäck, BY Farahmand, C Rosen, N Mattsson… - Brain, 2015 - academic.oup.com
CSF amyloid-β 1-42 and high total tau and phosphorylated tau are associated with cognitive
… Further, we hypothesized that high total tau and low amyloid-β 1-42 would be most …

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

A Leuzy, K Chiotis, SG Hasselbalch, JO Rinne… - Brain, 2016 - academic.oup.com
amyloid-β 42 using a Meso Scale Discovery enzyme linked … included subjects with normal
cognition and patients with mild … CSF amyloid-β (amyloid-β 42 and amyloid-β 42/40 ) using …

Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study

J Dumurgier, S Schraen, A Gabelle… - Alzheimer's research & …, 2015 - Springer
cognitive impairment (MCI) represented a heterogeneous group, including patients with and
without AD-related … Using a large prospective multicenter cohort of patients with cognitive

Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults

AM Fagan, CM Roe, C Xiong, MA Mintun… - Archives of …, 2007 - jamanetwork.com
Individuals with very mild or mild AD have reduced mean levels of CSF42 and increased
levels of CSF … of Aβ 42 -related CSF measures to discriminate individuals with amyloid …