High shear granulation

GK Reynolds, PK Le, AM Nilpawar - Handbook of powder technology, 2007 - Elsevier
… For melt granulation, binder can be added as a solid to a preheated high shear granulator. …
in high shear granulators. Much of the wealth of literature concerning granulation considers …

A review of high shear wet granulation for better process understanding, control and product development

B Liu, J Wang, J Zeng, L Zhao, Y Wang, Y Feng… - Powder Technology, 2021 - Elsevier
… The granulating module of a high shear wet granulator mainly consists of a mixing bowl, an
granulation endpoint control. The granulating module of the commonly used high shear wet …

High-shear granulation

R Gokhale, Y Sun, AJ Shukla - … of pharmaceutical granulation …, 2005 - taylorfrancis.com
high dose, are often granulated prior to compression into tablets. Thus, the overall purpose
of granulation … Besides improving the flowability and compressibility, the granulation process …

Direct evidence of heterogeneity during high-shear granulation

AC Scott, MJ Hounslow, T Instone - Powder Technology, 2000 - Elsevier
… PEG and lactose systems in high-shear melt granulation. They use an apparent density
difference method to calculate their porosity and report much higher values than are seen here …

On control of particle size distribution in granulation using high-shear mixers

M Bardin, PC Knight, JPK Seville - Powder Technology, 2004 - Elsevier
… in fluidised beds and is particularly acute with ‘high-shear’ types of mixer. With the … high-speed
or high-shear mixers. This paper is concerned principally with granulation in high-shear

Coupling granule properties and granulation rates in high-shear granulation

CA Biggs, C Sanders, AC Scott, AW Willemse… - Powder Technology, 2003 - Elsevier
… The aim of this paper, therefore, is to model the high-shear granulationgranulation process.
Comparison is then made between experimental and simulated results of the granulation

Characterisation of granule structure and strength made in a high shear granulator

N Rahmanian, M Ghadiri, X Jia, F Stepanek - Powder Technology, 2009 - Elsevier
… The granules used in this work were produced at three different impeller speeds in a high
shear granulator. The measurement of strength of these granules by side crushing test method …

Effects of high-shear granulation on granulate homogeneity

H Vromans, HGM Poels-Janssen… - Pharmaceutical …, 1999 - Taylor & Francis
… it can be concluded that high-shear mixing itself is attributable to the demixing phenomenon.
Therefore, it is obvious that it is better to avoid high shear during granulation, in particular if …

High shear seeded granulation: Its preparation mechanism, formulation, process, evaluation, and mathematical simulation

R Maharjan, SH Jeong - Powder Technology, 2020 - Elsevier
… Important advantages of high shear granulation are granule densification, better … illustration
of high shear seeded granulation with low shear granulation, FBG, and melt granulation is …

Development of a predictive high-shear granulation model

CFW Sanders, AW Willemse, AD Salman… - Powder Technology, 2003 - Elsevier
… of the high shear granulation process as it is … high shear granulation processes is often
still more an art than a science. In order to bring more science, we aim to describe granulation