… mice exhibited acceleration of spontaneous age-related and … -fed mice exhibited a distinct
and sustained plasma metabolite … is the first to describe a distinct and sustained HFD-induced …

Aims The aim of this study was to systematically review the literature for evidence of the effect
of a high-fat diet (HFD) on the onset or progression of osteoarthritis (OA) in mice. Methods …

… speed (4 to 40 rpm over 5 minutes) and constant speed (24 … and HG mice having accelerated
loss compared with controls … by a high-fat diet and correspond to osteoarthritis severity, we …

… accelerated tidemark advancement associated with a decrease in proteoglycan content [8]. …
and mechanical loading associated with weight gain each serve a unique function in the …

… to high fat or western-type diets result in OA-related changes … changes related to obesity in
two groups of different mass but … increased damage at an accelerated rate. Although this was …

… of chronic consumption of a high-fat or high-fat/high-sugar (… Diet-induced obesity accelerates
IVD degeneration and … has also been suggested to contribute to osteoarthritis (OA) [16], a …

… by linking a high-fat diet with accelerated OA onset and … Severity scores demonstrated
clear mouse-strain-dependent … While blood glucose of HFD-fed mice remained at a constant …

… to induce or accelerate diet-induced OA progression in the … is small upon high-fat feeding
alone, but will be accelerated in … to be a result of the constant biomechanical stress 37 , 38 . We …

… Mice were maintained under a constant temperature of 20 ± 2 C, … Different proportions of
fat in a diet may also affect the onset of OA, with a higher fat content associated with accelerated …

… mouse model of high-fat diet-induced obesity to investigate … were collected hourly over a
continuous 20-h period, and the … of samples using two different methods following manufacturer …