High-level expression of a full-length Eph receptor
S Paavilainen, D Grandy, E Karelehto, E Chang… - Protein expression and …, 2013 - Elsevier
Eph receptors are the largest family of Receptor Tyrosine Kinases containing a single
membrane-spanning segment. They are involved in a various developmental and cell–cell
communication events. Although there is extensive structural information available on both
the extra-and intracellular regions of Eph's in isolation, no structures are available for the
entire receptor. To facilitate structural studies on functionally relevant Eph/ephrin complexes,
we have developed an expression system for producing the full-length human EphA2 …
membrane-spanning segment. They are involved in a various developmental and cell–cell
communication events. Although there is extensive structural information available on both
the extra-and intracellular regions of Eph's in isolation, no structures are available for the
entire receptor. To facilitate structural studies on functionally relevant Eph/ephrin complexes,
we have developed an expression system for producing the full-length human EphA2 …
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