High-Resolution SNP/CGH Microarrays Reveal the Accumulation of Loss of Heterozygosity in Commonly Used Candida albicans Strains
Phenotypic diversity can arise rapidly through loss of heterozygosity (LOH) or by the
acquisition of copy number variations (CNV) spanning whole chromosomes or shorter
contiguous chromosome segments. In Candida albicans, a heterozygous diploid yeast
pathogen with no known meiotic cycle, homozygosis and aneuploidy alter clinical
characteristics, including drug resistance. Here, we developed a high-resolution microarray
that simultaneously detects∼ 39,000 single nucleotide polymorphism (SNP) alleles and∼ …
acquisition of copy number variations (CNV) spanning whole chromosomes or shorter
contiguous chromosome segments. In Candida albicans, a heterozygous diploid yeast
pathogen with no known meiotic cycle, homozygosis and aneuploidy alter clinical
characteristics, including drug resistance. Here, we developed a high-resolution microarray
that simultaneously detects∼ 39,000 single nucleotide polymorphism (SNP) alleles and∼ …