The ability to detect, respond and adapt to mitochondrial stress ensures the development
and survival of organisms. Caenorhabditis elegans responds to mitochondrial stress by
activating the mitochondrial unfolded protein response (UPRmt) to buffer the mitochondrial
folding environment, rewire the metabolic state, and promote innate immunity and lifespan
extension. Here we show that HDA-1, the C. elegans ortholog of mammalian histone
deacetylase (HDAC) is required for mitochondrial stress-mediated activation of UPRmt. HDA …