Hla-mapper: An application to optimize the mapping of HLA sequences produced by massively parallel sequencing procedures
EC Castelli, MA Paz, AS Souza, J Ramalho… - Human immunology, 2018 - Elsevier
A challenging task when more than one HLA gene is evaluated together by second-
generation sequencing is to achieve a reliable read mapping. The polymorphic and
repetitive nature of HLA genes might bias the read mapping process, usually
underestimating variability at very polymorphic segments, or overestimating variability at
some segments. To overcome this issue we developed hla-mapper, which takes into
account HLA sequences derived from the IPD-IMGT/HLA database and unpublished HLA …
generation sequencing is to achieve a reliable read mapping. The polymorphic and
repetitive nature of HLA genes might bias the read mapping process, usually
underestimating variability at very polymorphic segments, or overestimating variability at
some segments. To overcome this issue we developed hla-mapper, which takes into
account HLA sequences derived from the IPD-IMGT/HLA database and unpublished HLA …
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