Alluvial and colluvial sequences were studied around the prehistoric tell Arslantepe in 11 exposures and additional auger cores. The chronology is based on 11 optically stimulated luminescence (OSL) ages, four radiocarbon ages, and the embedded artifacts. Sediments contained wood charcoals, providing information on former vegetation. Fluvial activity is documented during Late Glacial times (15.4 ± 2.5, 12.8 ± 3.1 kyr) and frequently after Roman times. Slope and soil erosion occurred in the early (10.6 ± 1.4, 8.2 ± 0.7 kyr) and mid–late Holocene (6.7 ± 0.9, 5.4 ± 0.7–4.7 ± 0.7, 2.6 ± 0.2–2.5 ± 0.2, 1.9 ± 0.2–1.8 ± 0.2 kyr, and during the last 1000 years). The early Holocene erosion phases pre-date the so far established onset of settlement at the tell. This either indicates an earlier onset of agricultural land use than assumed or climatic influence on erosion, such as the 10.3 and 8.2 kyr climate events known from Western Europe. The erosion phases at around 5.0 and 2.6 kyr could reflect geomorphic responses to societal collapse (Late Chalcolithic state, Neo-Hittite kingdom) at Arslantepe. Most intensive Holocene soil erosion and landscape degradation occurred after occupation of the region by the Roman Empire. This is paralleled by the onset of river activity. A part of the lower neo-Hittite town as well as an early Holocene Terra Rossa–like soil that had formed rapidly were found buried. So far, no indication for mid–late Holocene fluvial activity of the adjacent creeks until Roman times has been found. Our results illustrate the large potential of slope deposits for long term reconstructions of human induced landscape transformation in Anatolia.