… These malformations generally are lumped under the term holoprosencephaly (HPE) coined
by DeMyer and Zeman in 1963.14,15 These authors further subdivided HPE into the well-…

… Holoprosencephaly and ectrodactyly: report of three new patients and review of the literature.
Am J Med Genet C Semin Med Genet 2010;154C(1):170–175. Crossref, Medline, Google …

… These original studies firmly established the concept that only a single genetic insult was
sufficient … We should be prepared for many new mechanistic surprises in the future, since only a …

… information regarding cardinal clinical and genetic concepts regarding holoprosencephaly,
with a special emphasis on clinical management and molecular diagnostic options available …

… Holoprosencephaly (HPE) is a common congenital … The new animal models described in
this review may help unravel these … Holoprosencephaly (HPE) is the most common structural …

… Holoprosencephaly is a malformation of the cerebral hemispheres resulting in the absence
… of holoprosencephaly. Herein is reviewed the syndromes associated with holoprosencephaly…

… In summary, holoprosencephaly is a continuum of structural brain anomalies resulting
from the failure of midline cleavage of the prosencephalon. The spectrum and severity of the …

… clinical features of holoprosencephaly, and neuropathologic … The traditional morphologic
classification of holoprosencephaly into … A new classification of holoprosencephaly is needed to …

… Holoprosencephaly (HPE) is a relatively rare brain malformation associated with a high …
HOLOPROSENCEPHALY Holoprosencephaly results from incomplete cleavage of the cerebral …

… Holoprosencephaly results from the incomplete midline cleavage of the prosencephalon. It
… miology of holoprosencephaly and phenotypic characteristics of affected children: New York …