Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide
D Sade Yazdi, D Laor Bar-Yosef… - Proceedings of the …, 2021 - National Acad Sciences
High levels of homocysteine are reported as a risk factor for Alzheimer's disease (AD).
Correspondingly, inborn hyperhomocysteinemia is associated with an increased
predisposition to the development of dementia in later stages of life. Yet, the mechanistic link
between homocysteine accumulation and the pathological neurodegenerative processes is
still elusive. Furthermore, despite the clear association between protein aggregation and
AD, attempts to develop therapy that specifically targets this process have not been …
Correspondingly, inborn hyperhomocysteinemia is associated with an increased
predisposition to the development of dementia in later stages of life. Yet, the mechanistic link
between homocysteine accumulation and the pathological neurodegenerative processes is
still elusive. Furthermore, despite the clear association between protein aggregation and
AD, attempts to develop therapy that specifically targets this process have not been …
Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide.
High levels of homocysteine are reported as a risk factor for Alzheimer's disease (AD).
Correspondingly, inborn hyperhomocysteinemia is associated with an increased
predisposition to the development of dementia in later stages of life. Yet, the mechanistic link
between homocysteine accumulation and the pathological neurodegenerative processes is
still elusive. Furthermore, despite the clear association between protein aggregation and
AD, attempts to develop therapy that specifically targets this process have not been …
Correspondingly, inborn hyperhomocysteinemia is associated with an increased
predisposition to the development of dementia in later stages of life. Yet, the mechanistic link
between homocysteine accumulation and the pathological neurodegenerative processes is
still elusive. Furthermore, despite the clear association between protein aggregation and
AD, attempts to develop therapy that specifically targets this process have not been …
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