Microbial infections of the cornea frequently cause painful, blinding and debilitating disease
that is often difficult to treat and may require corneal transplantation. In addition, sterile …

… contribute to the external ocular defense mechanisms (see … It is believed to be of both lacrimal
and ocular surface tissue … a vital role in the external ocular host defense. SLPI contains two …

… defend the ocular surface against diverse … host defense. And, it is clear that close integration
of these various mechanisms provides a highly efficient amplification system for host defense…

… defense mechanisms has evolved to protect the outer eye. These host defense mechanisms
… , nonspecific defense or a specifically acquired immunological defense requiring previous …

… have been identified at the ocular surface. In addition to their … the ocular surface; (2)
participation of HDPs in ocular surface … , rosacea keratitis, and post-ocular surgery; (3) HDPs that …

… Our preliminary studies in human ocular surface epithelia suggest that MUC1 is up-regulated
by infection, inflammation, and stress. This supports the idea that the extracellular O-…

… A range of bacteria, including mycobacteria tuberculosis, viruses including herpes virus,
fungi and parasites including acanthamoeba, that cause ocular infections have been shown to …

… The ocular surface epithelium serves a critical function as the defensive front line of the …
While the detection of microbes is arguably its most important task, an exaggerated host defense …

… Although their role in physiological host defense is poorly understood, they are potentially
useful cells. They are mainly known, however, for their deleterious inflammatory activity during …

… by augmenting IL-17 production by ocular surface cells and CD4 + T cells 30 . The role of
γδ T cells in host defense of the ocular surface in relation to the commensal microbiome has …