[PDF][PDF] How can an overlapping mechanism lead to distinct pathology? The case of psychosis and obsessive compulsive disorder
… To the Editor: We thank Poletti and Raballo (2019; this issue) for their thought-provoking
letter. We agree that a gradient of impairments in sensorimotor predictions can help explain
some phenotypic and genetic overlaps between schizophrenia spectrum disorders (SSD)
and obsessive compulsive disorder (OCD). We would like to add two points addressing the
differences between these disorders. First, sensorimotor predictions are often incorporated
in a broader predictive coding framework in which the brain is viewed as a hierarchical …
letter. We agree that a gradient of impairments in sensorimotor predictions can help explain
some phenotypic and genetic overlaps between schizophrenia spectrum disorders (SSD)
and obsessive compulsive disorder (OCD). We would like to add two points addressing the
differences between these disorders. First, sensorimotor predictions are often incorporated
in a broader predictive coding framework in which the brain is viewed as a hierarchical …
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