Small and medium sized entrepreneurship (SME) is often considered a contemporary phenomenon. Why have so many authors dedicated their work to this field? The main reason is that SME influences society and contributes to the economic development of its region. This analysis emphasizes endogenous factors for success. The situation in the Moravia-Silesian Region (the northeast region of the Czech Republic) in which we applied factor analysis on a research sample supported our hypothesis. Moreover, we used VRIO analysis to clearly interpret our research findings.