Although species-specific differences in ion channel properties are well-documented, little
has been known about the properties of the human Nav1. 8 channel, an important
contributor to pain signaling. Here we show, using techniques that include voltage clamp,
current clamp, and dynamic clamp in dorsal root ganglion (DRG) neurons, that human Nav1.
8 channels display slower inactivation kinetics and produce larger persistent current and
ramp current than previously reported in other species. DRG neurons expressing human …

Although species-specific differences in ion channel properties are well-documented, 25
little has been known about the properties of the human Nav1. 8 channel, an important 26
contributor to pain signaling. Here we show, using techniques that include voltage-clamp, 27
current-clamp and dynamic clamp in dorsal root ganglion (DRG) neurons, that human Nav1.
8 28 channels display slower inactivation kinetics, and produce larger persistent current and
ramp 29 current than previously reported in other species. DRG neurons expressing human …