[PDF][PDF] Human embryonic genome activation initiates at the one-cell stage
In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we
profiled gene expression at depth in human metaphase II oocytes and bipronuclear (2PN)
one-cell embryos. High-resolution single-cell RNA sequencing revealed previously
inaccessible oocyte-to-embryo gene expression changes. This confirmed transcript
depletion following fertilization (maternal RNA degradation) but also uncovered low …
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we
profiled gene expression at depth in human metaphase II oocytes and bipronuclear (2PN)
one-cell embryos. High-resolution single-cell RNA sequencing revealed previously
inaccessible oocyte-to-embryo gene expression changes. This confirmed transcript
depletion following fertilization (maternal RNA degradation) but also uncovered low …
[引用][C] Human embryonic genome activation initiates at the one-cell stage (Supplementary Tables)
Human embryonic genome activation initiates at the one-cell stage (Supplementary Tables) …
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