Human herpesvirus 7, Epstein–Barr virus and human cytomegalovirus in periodontal tissues of periodontally diseased and healthy subjects
Journal of clinical periodontology, 2008•Wiley Online Library
Aims: To evaluate (i) the presence of human herpesvirus 7 (HHV‐7), Epstein–Barr virus
(EBV) and human cytomegalovirus (HCMV), and (ii) the transcription pattern of HHV‐7 in
gingival biopsies from patients affected by periodontitis (P) and periodontally healthy
subjects (H). Material and Methods: Thirty‐seven subjects (P: n= 24; H: n= 13) were
included. Each P patient contributed two gingival biopsies (representative of a clinically
affected and non‐affected site) and each H subject contributed one gingival biopsy. After …
(EBV) and human cytomegalovirus (HCMV), and (ii) the transcription pattern of HHV‐7 in
gingival biopsies from patients affected by periodontitis (P) and periodontally healthy
subjects (H). Material and Methods: Thirty‐seven subjects (P: n= 24; H: n= 13) were
included. Each P patient contributed two gingival biopsies (representative of a clinically
affected and non‐affected site) and each H subject contributed one gingival biopsy. After …
Abstract
Aims: To evaluate (i) the presence of human herpesvirus 7 (HHV‐7), Epstein–Barr virus (EBV) and human cytomegalovirus (HCMV), and (ii) the transcription pattern of HHV‐7 in gingival biopsies from patients affected by periodontitis (P) and periodontally healthy subjects (H).
Material and Methods: Thirty‐seven subjects (P: n=24; H: n=13) were included. Each P patient contributed two gingival biopsies (representative of a clinically affected and non‐affected site) and each H subject contributed one gingival biopsy. After DNA extraction, nested polymerase chain reaction was used to identify the viruses.
Results: HHV‐7 was detected in 91.7% of P patients and in 61.5% of H subjects (p=0.02), EBV in 50.0% samples of P patients and 7.7% of H subjects (p=0.005) and HCMV only in one sample from H group. EBV was more frequently detected in biopsies from affected sites (50.0%) than from non‐affected sites (16.7%) (p=0.008). HHV‐7 transcription was detected in 15.4% of affected and 15.4% of non‐affected sites.
Conclusions: The results indicate that (i) gingival tissues can be considered a potential reservoir for HHV‐7; (ii) when present, HHV‐7 persists in a latent state in the majority of cases; (iii) the presence of EBV seems to be associated with the diseased state of the patient and site.
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