Human histone H3K79 methyltransferase DOT1L methyltransferase binds actively transcribing RNA polymerase II to regulate gene expression
Histone-modifying enzymes play a pivotal role in gene expression and repression. In
human, DOT1L (Dot1-like) is the only known histone H3 lysine 79 methyltransferase.
hDOT1L is associated with transcriptional activation, but the general mechanism connecting
hDOT1L to active transcription remains largely unknown. Here, we report that hDOT1L
interacts with the phosphorylated C-terminal domain of actively transcribing RNA
polymerase II (RNAPII) through a region conserved uniquely in multicellular DOT1 proteins …
human, DOT1L (Dot1-like) is the only known histone H3 lysine 79 methyltransferase.
hDOT1L is associated with transcriptional activation, but the general mechanism connecting
hDOT1L to active transcription remains largely unknown. Here, we report that hDOT1L
interacts with the phosphorylated C-terminal domain of actively transcribing RNA
polymerase II (RNAPII) through a region conserved uniquely in multicellular DOT1 proteins …
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