Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane
Y Wang, DF Bogenhagen - Journal of Biological Chemistry, 2006 - ASBMB
Mitochondrial DNA (mtDNA) is packaged into bacterial nucleoid-like structures, each
containing several mtDNA molecules. The distribution of nucleoids during mitochondrial
fission and fusion events and during cytokinesis is important to the segregation of
mitochondrial genomes in heteroplasmic cells bearing a mixture of wild-type and mutant
mtDNA molecules. We report fractionation of HeLa cell mtDNA nucleoids into two subsets of
complexes that differ in their sedimentation velocity and their association with cytoskeletal …
containing several mtDNA molecules. The distribution of nucleoids during mitochondrial
fission and fusion events and during cytokinesis is important to the segregation of
mitochondrial genomes in heteroplasmic cells bearing a mixture of wild-type and mutant
mtDNA molecules. We report fractionation of HeLa cell mtDNA nucleoids into two subsets of
complexes that differ in their sedimentation velocity and their association with cytoskeletal …
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