Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

IA Shopova, I Belyaev, P Dasari, S Jahreis, MC Stroe… - MBio, 2020 - Am Soc Microbiol
… to that of a control strain producing the human retinol binding protein 7. In conclusion,
extracellular vesicles produced by neutrophils in response to A. fumigatus infection are able to …

[PDF][PDF] Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11: e00596-20

IA Shopova, I Belyaev, P Dasari, S Jahreis, MC Stroe… - 2020 - d-nb.info
… mechanism of neutrophil-mediated antifungal activity remains unresolved. Here, we present
a mode of antifungal defense employed by human neutrophils against A. fumigatus not …

Characterization of Aspergillus fumigatus Extracellular Vesicles and Their Effects on Macrophages and Neutrophils Functions

JAM Souza, LM Baltazar, VM Carregal… - Frontiers in …, 2019 - frontiersin.org
… We investigated the capacity of EVs to stimulate bone marrow-derived neutrophils (BMDN)
and to improve their fungicide capacity. After 3 h of EVs stimulation, there was a pattern of …

PLB-985 neutrophil-like cells release antifungal extracellular vesicles against the human-pathogenic fungus Aspergillus fumigatus

M Rafiq, F Rivieccio, AK Zimmermann, C Visser… - bioRxiv, 2021 - biorxiv.org
… -derived extracellular vesicles of human neutrophils is likely their antifungal capacity, as
we previously reported (10). We set out to determine if the extracellular vesicles produced by …

PLB-985 neutrophil-like cells as a model to study Aspergillus fumigatus pathogenesis

M Rafiq, F Rivieccio, AK Zimmermann, C Visser… - Msphere, 2022 - Am Soc Microbiol
… method for the isolation of extracellular vesicles produced during infection by employing a
… -derived extracellular vesicles of human neutrophils is likely their antifungal capacity, as we …

Aspergillus fumigatus Extracellular Vesicles Display Increased Galleria mellonella Survival but Partial Pro-Inflammatory Response by Macrophages

MS Freitas, TA Bitencourt, CP Rezende, NS Martins… - Journal of Fungi, 2023 - mdpi.com
fumigatus EVs could be exploited in antifungal therapies. … fumigatus induce NET formation
by human neutrophils [44,45]. In the … NET formation by human neutrophils. NETs released by …

Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatus

C Visser, F Rivieccio, T Krüger, F Schmidt… - microLife, 2024 - academic.oup.com
produce antifungal EVs targeting the clinically important fungal pathogen Aspergillus fumigatus
association and apparent internalization of human primary neutrophil-derived EVs into A. …

Extracellular Vesicles from Aspergillus flavus Induce M1 Polarization In Vitro

VS Brauer, AM Pessoni, TA Bitencourt, RG de Paula… - Msphere, 2020 - Am Soc Microbiol
Extracellular vesicles (EVs) are structures produced by all life domains; they range in size …
Aspergillus fumigatus extracellular vesicles and their effects on macrophages and neutrophils

Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens

P Brandt, R Singha, IV Ene - mBio, 2024 - journals.asm.org
… This requires the development of vaccines and the advancement of antifungal strategies. …
Aspergillus fumigatus extracellular vesicles and their effects on macrophages and neutrophils

[HTML][HTML] Eradicating, retaining, balancing, swarming, shuttling and dumping: a myriad of tasks for neutrophils during fungal infection

CF Urban, E Backman - Current opinion in microbiology, 2020 - Elsevier
extracellular traps (NETs) and of extracellular vesicles (EVs), as … infection (OPC) [8] and
Aspergillus fumigatus pneumonia [9]. Both IL-… Contrarily, human neutrophils seem to use CR3 for …