lack of a fetal hemoglobin gene equivalent. This summary describes novel preclinical
humanized mouse models of CA that survive on human fetal hemoglobin at birth and are
blood‐transfusion dependent for life upon completion of their human fetal‐to‐adult
hemoglobin switch after birth. These CA models are the first to recapitulate the temporal
onset of the disease in human patients. These novel humanized CA disease models are …