Recent developments in database research introduced HTAP systems that are capable of handling both transactional and analytical workloads. These systems achieve their performance by storing the full data set in main memory. An open research question is how far one can reduce the main memory footprint without losing the performance superiority of main memory-resident databases. In this paper, we present a hybrid main memory-optimized database for mixed workloads that evicts cold data to less expensive storage tiers. It adapts the storage layout to mitigate the negative performance impact of secondary storage. A key challenge is to determine which data to place on which storage tier. We introduce a novel workload-driven model that determines Pareto-optimal allocations while also considering reallocation costs. We evaluate our concept for a production enterprise system as well as reproducible data sets.