The paraventricular nucleus (PVN) of the hypothalamus is an important homeostatic and
reflex center for neuroendocrine, respiratory, and autonomic regulation, including during
hypoxic stressor challenges. Such challenges increase reactive oxygen species (ROS) to
modulate synaptic, neuronal, and ion channel activity. Previously, in the nucleus tractus
solitarius, another cardiorespiratory nucleus, we showed that the ROS H2O2 induced
membrane hyperpolarization and reduced action potential discharge via increased K+ …

The paraventricular nucleus (PVN) of the hypothalamus is an important center for
neuroendocrine, respiratory and autonomic regulation. The PVN has reciprocal innervation
with the nucleus tractus solitarii (nTS) and both are activated by exposure to low oxygen
(hypoxia). Hypoxia induces increased reactive oxygen species (ROS) production. Previously
we've shown in the nTS that the ROS hydrogen peroxide (H2O2) hyperpolarized membrane
potential and reduced action potential discharge via an increase in potassium conductance …