Protein tyrosine kinases (PTKs) are a group of closely related enzymes that have
evolutionarily diverged from serine/threonine kinases (STKs) to regulate pathways
associated with multi-cellularity. Evolutionary divergence of PTKs from STKs has occurred
through accumulation of mutations in the active site as well as in the commonly conserved
hydrophobic core. While the functional significance of active site variations is well
understood, relatively little is known about how hydrophobic core variations contribute to …

Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine
Kinase Evolution and Functional Specializati … (2016) Hydrophobic Core Variations
Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.
PLoS Genet 12(2): e1005885. doi: 10.1371/journal.pgen.1005885 … This is an open
access article distributed under the terms of the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the …