Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism
Our previous studies found that Astragalus polysaccharide (APS) exerts insulin-sensitizing
and hypoglycemic activities in type 2 diabetic (T2DM) rats. The present study was designed
to further confirm the hypoglycemic effect of APS and to investigate its possible mechanism
underlying the improvement of insulin resistance in vivo and in vitro. Diet-induced insulin
resistant C57BL/6J mice treated with or without APS (orally, 700mg/kg/d) for 8 weeks were
analyzed and compared. Simultaneously, an insulin resistant C2C12 cell model and an ER …
and hypoglycemic activities in type 2 diabetic (T2DM) rats. The present study was designed
to further confirm the hypoglycemic effect of APS and to investigate its possible mechanism
underlying the improvement of insulin resistance in vivo and in vitro. Diet-induced insulin
resistant C57BL/6J mice treated with or without APS (orally, 700mg/kg/d) for 8 weeks were
analyzed and compared. Simultaneously, an insulin resistant C2C12 cell model and an ER …
Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism.
MXQ Mao XianQing, YF Yu Feng, WN Wang Nian… - 2009 - cabidigitallibrary.org
Our previous studies found that Astragalus polysaccharide (APS) exerts insulin-sensitizing
and hypoglycemic activities in type 2 diabetic (T2DM) rats. The present study was designed
to further confirm the hypoglycemic effect of APS and to investigate its possible mechanism
underlying the improvement of insulin resistance in vivo and in vitro. Diet-induced insulin
resistant C57BL/6J mice treated with or without APS (orally, 700 mg/kg/d) for 8 weeks were
analyzed and compared. Simultaneously, an insulin resistant C2C12 cell model and an ER …
and hypoglycemic activities in type 2 diabetic (T2DM) rats. The present study was designed
to further confirm the hypoglycemic effect of APS and to investigate its possible mechanism
underlying the improvement of insulin resistance in vivo and in vitro. Diet-induced insulin
resistant C57BL/6J mice treated with or without APS (orally, 700 mg/kg/d) for 8 weeks were
analyzed and compared. Simultaneously, an insulin resistant C2C12 cell model and an ER …
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