IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
GD Kalliolias, LB Ivashkiv - The Journal of Immunology, 2008 - journals.aai.org
IL-27 is a member of the IL-12 family of cytokines that activates the Jak-STAT signaling
pathway in a context-dependent manner and has pleiotropic effects on acquired immunity. IL-
27 has the capacity to promote early stages of Th1 generation, but recent evidence has
suggested a predominant suppressive effect on Th1, Th2, and Th17 differentiation. Although
modest suppressive effects of IL-27 on myeloid lineage cells have been observed, there is
limited knowledge about the role of IL-27 in the regulation of innate immunity. In this study …
pathway in a context-dependent manner and has pleiotropic effects on acquired immunity. IL-
27 has the capacity to promote early stages of Th1 generation, but recent evidence has
suggested a predominant suppressive effect on Th1, Th2, and Th17 differentiation. Although
modest suppressive effects of IL-27 on myeloid lineage cells have been observed, there is
limited knowledge about the role of IL-27 in the regulation of innate immunity. In this study …
[引用][C] IL-27 activates human monocytes via STAT1 and suppresses IL-10 production, but the inflammatory functions of IL-27 are abrogated by TLRs and p38
K GD - J Immunol, 2008 - cir.nii.ac.jp
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production, but the
inflammatory functions of IL-27 are abrogated by TLRs and p38 | CiNii Research … IL-27
activates human monocytes via STAT1 and suppresses IL-10 production, but the
inflammatory functions of IL-27 are abrogated by TLRs and p38 …
inflammatory functions of IL-27 are abrogated by TLRs and p38 | CiNii Research … IL-27
activates human monocytes via STAT1 and suppresses IL-10 production, but the
inflammatory functions of IL-27 are abrogated by TLRs and p38 …
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