[HTML][HTML] IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation
SE Russell, RM Horan, AM Stefanska, A Carey… - Mucosal …, 2016 - Elsevier
A role for the IL-36 family of cytokines has been identified in the pathogenesis of psoriasis.
Although significant mechanistic overlap can exist between psoriasis and inflammatory
bowel disease (IBD), to date there have been no reports investigating the IL-36 family in
gastrointestinal inflammation. Here we demonstrate that expression levels of IL-36α are
specifically elevated in the colonic mucosa of ulcerative colitis patients. This elevated
expression is mirrored in the inflamed colonic mucosa of mice, wherein IL-36 receptor …
Although significant mechanistic overlap can exist between psoriasis and inflammatory
bowel disease (IBD), to date there have been no reports investigating the IL-36 family in
gastrointestinal inflammation. Here we demonstrate that expression levels of IL-36α are
specifically elevated in the colonic mucosa of ulcerative colitis patients. This elevated
expression is mirrored in the inflamed colonic mucosa of mice, wherein IL-36 receptor …
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