Objectives: Poly (ADP-ribose) polymerase (PARP) activation plays a key role in free radical
induced injury in the context of ischemia/reperfusion. In the present study, we investigated
the effects of INO-1001 a novel ultrapotent PARP inhibitor on postischemic myocardial and
endothelial function in a canine heart transplantation model. Material and Methods: After 4
hours of ischemic preservation, 12 orthotopic heart transplantations were performed. At the
beginning of reperfusion either saline vehicle (control, n= 6), or INO-1001 (1mg/kg, n= 6) …

Abstract Poly (ADP-ribose) polymerase (PARP) activation plays a key role in free radical–
induced injury in the context of systemic inflammation and ischemia/reperfusion. In the
present preclinical study, we investigated the effects of INO-1001, a novel PARP inhibitor, on
cardiac and pulmonary function during reperfusion in an experimental model of cardioplegic
arrest and extracorporal circulation. Twelve anesthetized dogs underwent hypothermic
cardiopulmonary bypass. After 60 min of hypothermic cardiac arrest, reperfusion was started …