IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity
Abstract Interleukin-1 receptor associated kinase 3 (IRAK3) is a cytoplasmic homeostatic
mediator of inflammatory responses and is potentially useful as a prognostic marker in
inflammation. IRAK3 inhibits signalling cascades downstream of myddosome complexes
associated with toll like receptors. IRAK3 contains a death domain that interacts with other
IRAK family members, a pseudokinase domain and a C-terminus domain involved with
tumour necrosis factor receptor associated factor 6 (TRAF6). Previous bioinformatic studies …
mediator of inflammatory responses and is potentially useful as a prognostic marker in
inflammation. IRAK3 inhibits signalling cascades downstream of myddosome complexes
associated with toll like receptors. IRAK3 contains a death domain that interacts with other
IRAK family members, a pseudokinase domain and a C-terminus domain involved with
tumour necrosis factor receptor associated factor 6 (TRAF6). Previous bioinformatic studies …
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