Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis
Journal of natural products, 2018•ACS Publications
Sesterterpenes are usually found in plants and fungi, but are rare in bacteria. Here, we
present the identification of StsC from Streptomyces somaliensis, a member of the UbiA
superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products
for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding
gene in an engineered Escherichia coli strain. The structures of 1 and 2 were determined by
analysis of the NMR and MS spectroscopic data.
present the identification of StsC from Streptomyces somaliensis, a member of the UbiA
superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products
for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding
gene in an engineered Escherichia coli strain. The structures of 1 and 2 were determined by
analysis of the NMR and MS spectroscopic data.
Sesterterpenes are usually found in plants and fungi, but are rare in bacteria. Here, we present the identification of StsC from Streptomyces somaliensis, a member of the UbiA superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding gene in an engineered Escherichia coli strain. The structures of 1 and 2 were determined by analysis of the NMR and MS spectroscopic data.
ACS Publications以上显示的是最相近的搜索结果。 查看全部搜索结果