Identification and characterization of nematode specific protective epitopes of Brugia malayi TRX towards development of synthetic vaccine construct for lymphatic …
J Madhumathi, PR Prince, G Anugraha, P Kiran… - Vaccine, 2010 - Elsevier
Although multi-epitope vaccines have been evaluated for various diseases, they have not
yet been investigated for lymphatic filariasis. Here, we report for the first time identification of
two immunodominant B epitopes (TRXP1 and TRXP2) from the antioxidant Brugia malayi
thioredoxin by studying their immune responses in mice model and human subjects. TRXP1
was also found to harbor a T epitope recognized by human PBMCs and mice splenocytes.
Further, the epitopic peptides were synthesized as a single peptide conjugate (PC1) and …
yet been investigated for lymphatic filariasis. Here, we report for the first time identification of
two immunodominant B epitopes (TRXP1 and TRXP2) from the antioxidant Brugia malayi
thioredoxin by studying their immune responses in mice model and human subjects. TRXP1
was also found to harbor a T epitope recognized by human PBMCs and mice splenocytes.
Further, the epitopic peptides were synthesized as a single peptide conjugate (PC1) and …
Identification and characterization of nematode specific protective epitopes of Brugia malayi TRX towards development of synthetic vaccine construct for lymphatic …
JM Jayaprakasam Madhumathi, PR Prince… - 2010 - cabidigitallibrary.org
Although multi-epitope vaccines have been evaluated for various diseases, they have not
yet been investigated for lymphatic filariasis. Here, we report for the first time identification of
two immunodominant B epitopes (TRXP1 and TRXP2) from the antioxidant Brugia malayi
thioredoxin by studying their immune responses in mice model and human subjects. TRXP1
was also found to harbor a T epitope recognized by human PBMCs and mice splenocytes.
Further, the epitopic peptides were synthesized as a single peptide conjugate (PC1) and …
yet been investigated for lymphatic filariasis. Here, we report for the first time identification of
two immunodominant B epitopes (TRXP1 and TRXP2) from the antioxidant Brugia malayi
thioredoxin by studying their immune responses in mice model and human subjects. TRXP1
was also found to harbor a T epitope recognized by human PBMCs and mice splenocytes.
Further, the epitopic peptides were synthesized as a single peptide conjugate (PC1) and …