Epigenetics regulations have an important role in fertilization and proper embryonic
development, and several human diseases are associated with epigenetic modification
disorders, such as Rett syndrome, Beckwith-Wiedemann syndrome and Angelman
syndrome. However, the dynamics and functions of long non-coding RNAs (lncRNAs), one
type of epigenetic regulators, in human pre-implantation development have not yet been
demonstrated. In this study, a comprehensive analysis of human and mouse early-stage …