Identification of Apolipoprotein E4 inhibitors for Alzheimer's Disease Therapy through a Large-Scale Virtual Screening
Abstract Alzheimer's disease (AD), a neurodegenerative disorder, is characterized by its
ability to cause memory loss and damage other cognitive functions. Aggregation of beta
amyloid plaques (Aβ) and neurofibrillary tangles in brain are responsible for the
development of Alzheimer's disease (AD). Apolipoprotein E4 allele (ApoE) is a high-risk
genetic factor for AD compared to other alleles. The ApoE4 protein has been shown to
increase Aβ accumulation by directly binding to Aβ as well as interfering with Aβ clearance …
ability to cause memory loss and damage other cognitive functions. Aggregation of beta
amyloid plaques (Aβ) and neurofibrillary tangles in brain are responsible for the
development of Alzheimer's disease (AD). Apolipoprotein E4 allele (ApoE) is a high-risk
genetic factor for AD compared to other alleles. The ApoE4 protein has been shown to
increase Aβ accumulation by directly binding to Aβ as well as interfering with Aβ clearance …
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