Identification of OtpR regulated sRNAs in Brucella melitensis expressed under acidic stress and their roles in pathogenesis and metabolism
US Vishnu, J Sankarasubramanian… - … and Infectious Diseases, 2017 - Elsevier
Small RNAs (sRNAs) are the small regulatory molecules that regulate various biological
processes in bacteria. Though the functions of sRNAs are well documented, very little
information is available on the sRNAs of Brucella spp. The otpR is the response regulator of
a two-component regulatory system, which plays a significant role in Brucella virulence. In
this study, we identified the sRNAs expressed in B. melitensis 16M and its otpR mutant
under acidic stress from the RNAseq dataset. We identified 94 trans-encoded and 948 cis …
processes in bacteria. Though the functions of sRNAs are well documented, very little
information is available on the sRNAs of Brucella spp. The otpR is the response regulator of
a two-component regulatory system, which plays a significant role in Brucella virulence. In
this study, we identified the sRNAs expressed in B. melitensis 16M and its otpR mutant
under acidic stress from the RNAseq dataset. We identified 94 trans-encoded and 948 cis …
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