Identifying lipidic emulsomes for improved oxcarbazepine brain targeting: In vitro and rat in vivo studies
GM El-Zaafarany, ME Soliman, S Mansour… - International journal of …, 2016 - Elsevier
Lipid-based nanovectors offer effective carriers for brain delivery by improving drug potency
and reducing off-target effects. Emulsomes are nano-triglyceride (TG) carriers formed of lipid
cores supported by at least one phospholipid (PC) sheath. Due to their surface active
properties, PC forms bilayers at the aqueous interface, thereby enabling encapsulated drug
to benefit from better bioavailability and stability. Emulsomes of oxcarbazepine (OX) were
prepared, aimed to offer nanocarriers for nasal delivery for brain targeting. Different TG …
and reducing off-target effects. Emulsomes are nano-triglyceride (TG) carriers formed of lipid
cores supported by at least one phospholipid (PC) sheath. Due to their surface active
properties, PC forms bilayers at the aqueous interface, thereby enabling encapsulated drug
to benefit from better bioavailability and stability. Emulsomes of oxcarbazepine (OX) were
prepared, aimed to offer nanocarriers for nasal delivery for brain targeting. Different TG …
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