Imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation
Recent studies have revealed an essential role for embryonic cortical development in the
pathophysiology of neurodevelopmental disorders, including autism spectrum disorder
(ASD). However, the genetic basis and underlying mechanisms remain unclear. Here, we
generate mutant human embryonic stem cell lines (Mut hESCs) carrying an NR2F1-R112K
mutation that has been identified in a patient with ASD features and investigate their
neurodevelopmental alterations. Mut hESCs overproduce ventral telencephalic neuron …
pathophysiology of neurodevelopmental disorders, including autism spectrum disorder
(ASD). However, the genetic basis and underlying mechanisms remain unclear. Here, we
generate mutant human embryonic stem cell lines (Mut hESCs) carrying an NR2F1-R112K
mutation that has been identified in a patient with ASD features and investigate their
neurodevelopmental alterations. Mut hESCs overproduce ventral telencephalic neuron …
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