As we age, the immune system undergoes a process of senescence accompanied by the
increased production of proinflammatory cytokines, a chronic subclinical condition named as
“inflammaging”. Emerging evidence from human and experimental models suggest that
immune senescence also affects the central nervous system and promotes neuronal
dysfunction, especially within susceptible neuronal populations. In this review we discuss
the potential role of immune aging, inflammation and metabolic derangement in …