Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) directly interacts
with host's epithelial and immune cells, leading to inflammatory response induction, which is
considered the hallmark of infection. The host immune system is programmed to facilitate the
clearance of viral infection by establishing a modulated response. However, SARS-CoV-2
takes the initiative and its various structural and non-structural proteins directly or indirectly
stimulate the uncontrolled activation of injurious inflammatory pathways through interaction …
with host's epithelial and immune cells, leading to inflammatory response induction, which is
considered the hallmark of infection. The host immune system is programmed to facilitate the
clearance of viral infection by establishing a modulated response. However, SARS-CoV-2
takes the initiative and its various structural and non-structural proteins directly or indirectly
stimulate the uncontrolled activation of injurious inflammatory pathways through interaction …
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