Background Despite the high prevalence of patient-reported antibiotic allergy (so-called
antibiotic allergy labels [AALs]) and their impact on antibiotic prescribing, incorporation of
antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is
not widespread. We aimed to evaluate the impact of an AAT-AMS program on AAL
prevalence, antibiotic usage, and appropriateness of prescribing. Methods AAT-AMS was
implemented at two large Australian hospitals during a 14-month period beginning May …

Methods A prospective multicentre cohort study was undertaken to evaluate the introduction
of AAT-AMS at two large Australian hospitals during a 14-month period from May 2015.
Baseline demographic, AAL history, age-adjusted Charlson co-morbidity index, infection
history and antibiotic usage for 12-months prior to (pre-AAT-AMS) and 3-months following
testing (post-AAT-AMS) were recorded for each participant. A patient was deemed to have
been de-labelled if≥ 1 AAL was removed. Study outcomes included the proportion of …