Impact of dissolved oxygen during UV-irradiation on the chemical composition and function of CHO cell culture media
SM Meunier, B Todorovic, EV Dare, A Begum… - PloS one, 2016 - journals.plos.org
Ultraviolet (UV) irradiation is advantageous as a sterilization technique in the
biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are
typically challenging to destroy, as well as smaller viruses that can be difficult to remove via
conventional separation techniques. In this work, we investigated the influence of oxygen in
the media during UV irradiation and characterized the effect on chemical composition using
NMR and LC-MS, as well as the ability of the irradiated media to support cell culture …
biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are
typically challenging to destroy, as well as smaller viruses that can be difficult to remove via
conventional separation techniques. In this work, we investigated the influence of oxygen in
the media during UV irradiation and characterized the effect on chemical composition using
NMR and LC-MS, as well as the ability of the irradiated media to support cell culture …
Impact of dissolved oxygen during UV-irradiation on the chemical composition and function of CHO cell culture media
B Todorovic, EV Dare, A Begum, SR Guillemette… - 2016 - uwspace.uwaterloo.ca
Ultraviolet (UV) irradiation is advantageous as a sterilization technique in the
biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are
typically challenging to destroy, as well as smaller viruses that can be difficult to remove via
conventional separation techniques. In this work, we investigated the influence of oxygen in
the media during UV irradiation and characterized the effect on chemical composition using
NMR and LC-MS, as well as the ability of the irradiated media to support cell culture …
biopharmaceutical industry since it is capable of targeting non-enveloped viruses that are
typically challenging to destroy, as well as smaller viruses that can be difficult to remove via
conventional separation techniques. In this work, we investigated the influence of oxygen in
the media during UV irradiation and characterized the effect on chemical composition using
NMR and LC-MS, as well as the ability of the irradiated media to support cell culture …
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