mortality, which may be reduced by goal-directed therapy (GDT). The aim of this multicentre,
RCT was to evaluate the impact of intraoperative GDT on major morbidity and mortality in
patients undergoing transthoracic oesophagectomy. Methods Adult patients undergoing
transthoracic oesophagectomy were randomised to receive either minimally invasive
intraoperative GDT (stroke volume variation< 8%, plus systolic BP maintained> 90 mm Hg …