An attempt has been made to correlate groundwater quantity and quality concerning land use and land cover in the city, Raipur, Chhattisgarh, India. The land-use land-cover (LULC) is one of the dynamic processes of the urbanization method in a city or cities in a developing country. To assess the land use and land cover classes, we have used the multi-temporal remote sensing LANDSAT data of the year 2000 and 2018. There are ten LULC classes are identified, such as settlement, road, cultivation, industry, drainage, river, open land, vegetation, canal, and water bodies. The result shows that the LULC changes are mainly associated within the settlement and the cultivated area in the highest degree from 2000 to till date (2018). A comparison of LULC between the years 2000 and 2018 indicates that anthropogenic activities like settlement, road, and industrial areas have been expanded. The spatiotemporal variation of the water table and water quality parameters such as electrical conductivity (EC), Total Dissolved Solids (TDS), and Nitrate (NO3) between the year 2000 and 2018 have also been studied. The result shows that significant changes in the groundwater quantity and quality in the study area are due to anthropogenic activity.