The study sought to assess the relationship between student’s use of social media and academic performance of tertiary institutions students in Ghana with a focus on Accra and Tema Metropolis. Questionnaire was used for collecting data. Out of one thousand copies of the questionnaire distributed, a valid response of 70.0% was retrieved. SPSS computer software was used to measure descriptive, correlation, regression among others. The study revealed that all the constructs of social media (dependent variable) had a significant positive relationship thus the independent variables (Facebook, Whatsapps, Yahoo Messenger, Skype, and Twitter) at level 0.01 with the dependent variable academic performance.