Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by acute
intestinal injury. Intestinal stem cell (ISC) renewal is required for gut regeneration in
response to acute injury. The Wnt/β-catenin pathway is essential for intestinal renewal and
ISC maintenance. We found that ISC expression, Wnt activity and intestinal regeneration
were all decreased in both mice with experimental NEC and in infants with acute active
NEC. Moreover, intestinal organoids derived from NEC-injured intestine of both mice and …
intestinal injury. Intestinal stem cell (ISC) renewal is required for gut regeneration in
response to acute injury. The Wnt/β-catenin pathway is essential for intestinal renewal and
ISC maintenance. We found that ISC expression, Wnt activity and intestinal regeneration
were all decreased in both mice with experimental NEC and in infants with acute active
NEC. Moreover, intestinal organoids derived from NEC-injured intestine of both mice and …
以上显示的是最相近的搜索结果。 查看全部搜索结果